Investigations of diterpene alkaloids isolated from Aconitum anthora L. and A. moldavicum L., and of aconitine-derived lipo-alkaloids
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[Investigation of the diterpene alkaloids of Aconitum species native to the Carpathian Basin].
Aconitum species accumulate highly toxic diterpene alkaloids, which have attracted considerable interest because of their complex structure, interesting chemistry and noteworthy physiological effects. The authors carried out phytochemical analysis of two Aconitum species native to the Carpathian Basin, aiming the isolation of diterpene alkaloids. The multistep chromatographic purification of th...
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The immunomodulatory activity of diterpene alkaloids from Aconitum lycoctonum L. (Ranunculaceae family) was evaluated; the alkaloid components were extracted from plants grown wild in the Apennines near Parma (Northern Italy). The diterpene alkaloid lycoctonine evaluated by means of HPLC and IR techniques reaches its highest value in flowers, followed by stems, roots and leaves, while the maxim...
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Aconitum carmichaelii is an important medicinal herb used widely in China, Japan, India, Korea, and other Asian countries. While extensive research on the characterization of metabolic extracts of A. carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene alkaloids, its biosynthetic pathway remains largely unknown. Biosynthesis of t...
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Ten diterpenoid alkaloids, including eight aconitine-type C₁₉-diterpenoid alkaloids and two hetisine-type C₂₀-diterpenoid alkaloids, were isolated from the secondary roots of Aconitum carmichaeli Debx., known as "Fuzi" in Chinese traditional herbal medicine. Their structures were established on the basis of their spectroscopic data and comparison with those of the literature. Among these alkalo...
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